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Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma
Author(s) -
Cheng MingFang,
Huang MaoSuan,
Lin ChunShu,
Lin LiHan,
Lee HerngSheng,
Jiang JhihCheng,
Hsia KanTai
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12361
Subject(s) - immunostaining , immunohistochemistry , pathology , medicine , cancer , cell , metastasis , cancer research , gene knockdown , oncology , biology , cell culture , genetics
Aims To investigate the relationship of matriptase expression in oral squamous cell carcinoma ( OSCC ) to clinicopathological characteristics, patient survival and cell‐invasive properties. Methods and results Matriptase expression in OSCC was evaluated by immunohistochemical staining, and its relationship to clinicopathological features and outcomes was assessed statistically. The sh RNA ‐mediated stable knockdown of matriptase in OSCC cells was used to analyse cell proliferation, migration and invasion in vitro . Matriptase immunostaining score was correlated with histopathological grade, clinical stage, positive lymph node and distant metastasis, and higher matriptase immunostaining score was associated significantly with poor prognosis. Elevated matriptase expression in oral cancer cell lines was a significant promoter of oral cancer cell migration and invasion. Conclusions Matriptase expression correlates with tumour progression and invasive capability in OSCC and may be an adverse prognostic marker for this cancer.