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Differentiation and histogenesis of syringomatous tumour of the nipple and low‐grade adenosquamous carcinoma: evidence for a common origin
Author(s) -
Boecker Werner,
Stenman Göran,
Loening Thomas,
Andersson Mattias K,
Sinn HansPeter,
Barth Peter,
Oberhellmann Felix,
Bos Inge,
Berg Tobias,
Marusic Zlatko,
Samoilova Vera,
Buchwalow Igor
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12358
Subject(s) - histogenesis , adenosquamous carcinoma , pathology , biology , epithelium , cholangiocyte , carcinoma , neoplastic transformation , malignant transformation , immunohistochemistry , adenocarcinoma , medicine , carcinogenesis , cancer , genetics
Aims Syringomatous tumour of the nipple and low‐grade adenosquamous carcinoma ( LGA d SC ) of the breast are regarded as distinct entities. To clarify the nature of these two lesions, we compared the expression of different lineage/differentiation markers in 12 syringomatous tumours of the nipple, nine LGA d SC s, and normal breast epithelium. Methods and results Using triple immunofluorescence labelling and quantitative RT ‐ PCR for keratins, p63, and smooth muscle actin, we demonstrated that syringomatous tumour and LGA d SC contain p63+/ K 5/14+ tumour cells, K 10+ squamous cells, and K 8/18+ glandular cells, with intermediary cells being found in both lineages. Identical p63+/ K 5/14+ cells were also found in the normal breast duct epithelium. Conclusions Our data provide evidence that syringomatous tumour of the nipple and LGA d SC are identical or nearly identical lesions. They contain p63+/ K 5/14+ cells as the key cells from which the K 10+ squamous lineage and the K 8/18+ glandular lineage arise. On the basis of our findings in normal breast tissue and associated benign lesions, we suggest that p63+/ K 5/14+ cells of the normal breast duct epithelium or early related cells might play a key role in the neoplastic transformation of both syringomatous tumour and LGA d SC . We propose that the differentiation patterns found in both lesions reflect the early ontogenetic stages of the normal breast epithelium.