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The t(14;18)(q32;q21)/ IGH – MALT 1 translocation in gastrointestinal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue ( MALT lymphoma)
Author(s) -
Zhang Shimin,
Wei Minqi,
Liang Qi,
Johnson Daisy,
Dow Nancy,
Nelson Ann,
Aguilera Nadine,
Auerbach Aaron,
Wang Guanghua
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12327
Subject(s) - malt lymphoma , mucosa associated lymphoid tissue , lymphoma , marginal zone , pathology , lymphatic system , biology , fluorescence in situ hybridization , chromosomal translocation , b cell , intestinal mucosa , medicine , immunology , antibody , gene , genetics , chromosome
Aims Studies have indicated that the t(14;18)(q32;q21)/ IGH – MALT 1 translocation is present in extranodal marginal zone lymphomas of mucosa‐associated lymphoid tissue ( MALT lymphoma). However, only a few studies have investigated the incidence of t(14;18)/ IGH – MALT 1 in primary gastrointestinal MALT lymphomas or in diffuse large B ‐cell lymphomas ( DLBCL ). The overall significance of t(14;18)/ IGH – MALT 1 in gastrointestinal MALT lymphomas is not clear. We examined 41 gastrointestinal MALT lymphoma and 23 DLBCL cases, with the aim of further understanding the role of t(14;18)/ IGH – MALT 1 in these diseases. Methods and results Fluorescence in‐situ hybridization ( FISH ) assays for the detection of t(14;18)/ IGH – MALT 1 and t(11;18)(q21;q21)/ API 2 – MALT 1 , along with immunostaining and histological evaluations, were performed on selected cases. Of the 64 analysed cases, one gastric MALT lymphoma and one colonic MALT lymphoma were positive for t(14;18)/ IGH – MALT 1 . Conclusions We describe what are, to our knowledge, the first reported primary colonic MALT lymphoma carrying t(14;18)(q32;q21)/ IGH – MALT 1 , and one of the few reported cases of gastric MALT lymphoma with this translocation. As this translocation is seen in only a few gastrointestinal MALT lymphomas, it is not useful as a diagnostic marker for routine clinical services. Although these findings suggest that t(14;18)/ IGH – MALT 1 is a rare molecular event in gastrointestinal MALT lymphomas and DLBCL s, further studies to elucidate the role of this genetic alteration in these diseases are indicated.