Premium
Coexistence of inflammatory hepatocellular adenomas with HNF1α‐inactivated adenomas: is there an association?
Author(s) -
Castain Claire,
Sempoux Christine,
Brunt Elizabeth M,
Causse Olivier,
Heitzmann Anne,
HernandezPrera Juan C,
Bail Brigitte,
Schirmacher Peter,
Thung Swan N,
Balabaud Charles,
BioulacSage Paulette
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12326
Subject(s) - hepatocellular adenoma , phenotype , adenoma , immunohistochemistry , pathology , genotype , medicine , biology , gastroenterology , gene , genetics
Aims To report the coexistence of inflammatory hepatocellular adenoma (IHCA) and HNF1α‐inactivated HCA ( H ‐ HCA ) in cases from a multicentre study. Methods and results We report nine cases with the coexistence of IHCA and H ‐ HCA ; eight occurred in women, and one in a man. The numbers of nodules and the sizes of the largest and smallest HCA s were variable. In one case, the nodules of the two different subtypes were discovered at different times. In all women, HCA s were histologically typical, regardless of their subtype, whereas H ‐ HCA in the man differed histologically from classic H‐ HCA . Conclusions These cases suggest that a predisposition to develop multiple adenomas, hypothetically caused by a ‘benign tumorigenic field effect’, although common to all HCAs, may result in different genotypes and phenotypes. Although this is rare, it is expected that more cases with the coexistence of different genotypes will emerge, owing to progress in the use of specific immunohistochemical approaches.