Premium
Annexin A 10 is an immunohistochemical marker for adenocarcinoma of the upper gastrointestinal tract and pancreatobiliary system
Author(s) -
Lu SuHsi,
Yuan RayHwang,
Chen YuLing,
Hsu HeyChi,
Jeng YungMing
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12229
Subject(s) - immunohistochemistry , pathology , adenocarcinoma , pancreas , urothelium , medicine , gastrointestinal tract , stomach , cancer , urinary bladder
Aims Annexin A 10 ( ANXA 10) is a calcium‐ and phospholipid‐binding protein expressed normally in the gastric mucosa. In this study, we evaluated the potential use of ANXA 10 as a diagnostic marker. Methods and results We observed ANXA 10 expression in the gastric mucosa, the Brunner gland of the duodenum and the urothelium, but absence of expression in other normal organs. Following the screening of 1327 primary carcinomas of major organs, we identified ANXA 10 expression in 46% of gastric, 72% of ampullary, 78% of pancreatic and 33% of biliary adenocarcinomas. ANXA 10 was expressed in 83% of non‐invasive urothelial carcinomas, but was expressed in only 9% of invasive urothelial carcinomas. ANAX 10 was rarely expressed in carcinomas of other organs. Of 227 metastatic adenocarcinomas, ANXA 10 was expressed in 83% of metastatic pancreatic and 47% of metastatic gastric adenocarcinomas, but was expressed in only 2% of metastatic adenocarcinomas from other organs. In the liver, the sensitivity and specificity for identifying the pancreas as the primary site of metastatic adenocarcinoma were 83 and 95%, respectively. Conclusion Our study results indicate that the inclusion of ANXA 10 in an immunohistochemical panel will be helpful in the differential diagnosis of adenocarcinoma of an unknown primary site.