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PBK / TOPK expression in non‐small‐cell lung cancer: its correlation and prognostic significance with K i67 and p53 expression
Author(s) -
Lei Bin,
Liu Shuguang,
Qi Wenjuan,
Zhao Yunfei,
Li Yumei,
Lin Ni,
Xu Xiaoyan,
Zhi Chen,
Mei Juanjuan,
Yan Zhimin,
Wan Liyan,
Shen Hong
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12215
Subject(s) - immunohistochemistry , lung cancer , lymph node , medicine , oncology , stage (stratigraphy) , cancer research , pathology , biology , paleontology
Aims The aim of this study was to evaluate the prevalence of PBK / TOPK ( PDZ ‐binding kinase/ T ‐ LAK cell‐originated protein kinase) expression, and explore the prognostic significance of PBK / TOPK expression alone and in combination with K i67 and p53 expression in non‐small‐cell lung cancer ( NSCLC ). Methods and results We detected PBK / TOPK expression in 30 samples of normal lung tissue, 32 lymph node metastases and 279 primary non‐small‐cell lung cancers by immunohistochemistry, and analysed the correlation of PBK / TOPK expression with K i67 and p53 expression in primary tumour tissues. The results showed that PBK / TOPK expression was higher in lymph node metastases (75%) than in primary tumours (44.8%) and normal lung tissues (0%). PBK / TOPK expression was associated with histological type, lymph node metastasis, and TNM stage, and was positively correlated with K i67 and p53 expression in NSCLC . Univariate and multivariate survival analyses showed that PBK / TOPK expression was significantly associated with an unfavourable prognosis in NSCLC . The prognosis of patients with tumours positive for both PBK / TOPK expression and K i67 or p53 expression was also significantly unfavourable. Conclusions PBK / TOPK expression is positively correlated with K i67 and p53 expression, and can be used as an independent prognostic factor in NSCLC .