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Does the prognosis of colorectal mucinous carcinoma depend upon the primary tumour site? Results from two independent databases
Author(s) -
Gao Peng,
Song Yongxi,
Xu Yingying,
Sun Zhe,
Sun Jingxu,
Xu Huimian,
Wang Zhenning
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12190
Subject(s) - colorectal cancer , medicine , adenocarcinoma , cancer , log rank test , oncology , stage (stratigraphy) , survival analysis , gastroenterology , carcinoma , pathology , biology , paleontology
Aims Mucinous adenocarcinoma ( MUC ) is a commonly studied histological subtype of colorectal adenocarcinoma. However, the prognostic value of MUC remains unclear, particularly in patients stratified by the primary tumour site. We aimed to analyse the prognostic value of MUC in colorectal cancer. Methods and results We utilized two independent data sets in this study: (i) the N ational C ancer I nstitute's S urveillance, E pidemiology and E nd R esults ( SEER ) data set, and (ii) the data set from a single C hinese institution (the D epartment of S urgical O ncology at the F irst H ospital of C hina M edical U niversity). Patient survival was analysed using K aplan– M eier survival curves, and comparisons were performed using the log‐rank test. MUC occurred more frequently in patients who exhibited higher pT category, higher pN category, higher TNM stage, left‐sided colon cancer and higher histological grade. Based on the SEER data set, MUC was an independent negative survival indicator in rectal cancer (HR 1.125, 1.056–1.199; P < 0.001). While there was no significant association in left‐sided colon cancer ( P > 1.000), MUC was an independent protective survival indicator in right‐sided colon cancer (HR 0.925, 0.888–0.962; P < 0.001). Conclusions MUC was associated independently with poorer outcome for rectal cancer and was an independent protective survival indicator in right‐sided colon cancer. MUC exhibited a different outcome depending on tumour position for patients with colorectal cancer.