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The role of glutamate decarboxylase 65 in gastric cancer development, progression, and prognosis
Author(s) -
Song Yongxi,
Li Shizheng,
Wang Zhenning,
Zhu Jinliang,
Gao Peng,
Wang Meixian,
Dong Yulan,
Xu Huimian
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12164
Subject(s) - immunohistochemistry , cancer , glutamate decarboxylase , stage (stratigraphy) , univariate analysis , multivariate analysis , medicine , oncology , biology , univariate , tumor progression , pathology , cancer research , multivariate statistics , enzyme , paleontology , statistics , mathematics , biochemistry
Aims Recent studies have revealed that glutamate decarboxylase 65 ( GAD 65) plays important roles in cancer progression. The role of GAD 65 in gastric cancer development, progression and prognosis is currently unknown, and we aimed to investigate this. Methods and results Immunohistochemistry revealed that GAD 65 expression in 313 gastric cancer tissues was significantly higher than in 60 adjacent non‐tumour tissues. Moreover, the expression level of GAD 65 significantly correlated with the depth of tumour invasion and TNM stage. GAD 65 expression level was a significant prognostic factor in univariate survival analysis, but did not remain an independent prognostic factor following C ox multivariate analysis. For tumours with an intermediate type growth pattern, when those showing low expression of GAD 65 were reclassified with expanding type tumours, and those showing high expression with infiltrative type tumours, there was a significant difference in prognosis between these two novel subgroups, and this remained a significant prognostic factor in multivariate analysis. Conclusions Our findings indicate that GAD 65 is involved in the development and progression of gastric cancer as a tumour oncoprotein. Further elucidation of the molecular mechanisms underlying the role of GAD 65 is warranted.