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Tumour‐associated macrophages might represent a favourable prognostic indicator in patients with papillary renal cell carcinoma
Author(s) -
Hutterer Georg C,
Pichler Martin,
Chromecki Thomas F,
Strini Karin A,
Klatte Tobias,
Pummer Karl,
Remzi Mesut,
Mannweiler Sebastian,
Zigeuner Richard
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12163
Subject(s) - papillary renal cell carcinomas , medicine , pathological , hazard ratio , stage (stratigraphy) , oncology , proportional hazards model , cancer , confidence interval , renal cell carcinoma , carcinoma , kidney cancer , pathology , biology , paleontology
Aims Tumour‐associated macrophages ( TAM ) have been reported to be regulators of progression in various human cancers. We evaluated the prognostic relevance of TAM in a large series of patients with papillary renal cell carcinoma ( PRCC ). Methods and results The impact of TAM on cancer‐specific survival ( CSS ) in 177 patients with PRCC was assessed using the K aplan– M eier method and log‐rank test. A multivariate C ox regression analysis was performed with respect to CSS . The presence of TAM was noted in 112 of 177 (63%) tumours and was associated statistically significantly with favourable pathological parameters, including low pathological T stage, node‐negative tumours, low tumour grade, absence of vascular invasion and papillary subtype (all P < 0.05), respectively. Five‐year CSS probabilities for patients with TAM ‐positive tumours were 93.5%, compared with 72.5% in patients with TAM ‐negative tumours, respectively ( P < 0.001). Multivariate analysis revealed node‐positive tumours, distant metastases and UICC stage (I versus II – IV ) as independent predictors of death from PRCC , whereas the presence of TAM was associated independently with favourable outcome (hazard ratio = 0.45, 95% confidence interval 0.24–0.84, P = 0.012). Conclusions The presence of TAM was shown independently to reduce the risk of death from cancer by 55%. The presence of TAM should therefore become part of routine pathology reporting in PRCC .