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Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours
Author(s) -
Yamamoto Hidetaka,
Handa Mizuki,
Tobo Taro,
Setsu Nokitaka,
Fujita Kohei,
Oshiro Yumi,
Mihara Yumi,
Yoshikawa Yasuji,
Oda Yoshinao
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12159
Subject(s) - leiomyosarcoma , immunohistochemistry , pathology , calponin , smooth muscle tumor , stromal cell , leiomyoma , pdgfra , metastasis , pleomorphism (cytology) , stromal tumor , biology , stomach , desmin , medicine , gist , cancer , gastroenterology , vimentin
Aims We aimed to elucidate the clinicopathological and immunohistochemical features of leiomyosarcoma ( LMS ) of the gastrointestinal ( GI ) tract. Methods and results We encountered seven cases of GI ‐ LMS in the colon ( n = 4), rectum ( n = 1), jejunum ( n = 1) and stomach ( n = 1). They ranged from 1 to 25 cm (median, 8.5 cm) in size and had high mitotic counts (median 38 per 50 high‐power fields). Morphologically, the tumours were composed mainly of spindle cells with eosinophilic cytoplasm and various degrees of nuclear atypia and pleomorphism. Immunohistochemically, the tumours were positive for α‐smooth muscle actin (86%), muscle‐specific actin (71%), desmin (86%), calponin (71%), h‐caldesmon (57%) and smoothelin (71%). All were negative for KIT , CD 34, protein kinase C theta and DOG 1. Local recurrence and distant metastasis occurred in one and three patients, respectively. We then reviewed 55 cases of GI ‐ LMS from the era following the recognition of gastrointestinal stromal tumours. Among 29 of 55 cases for whom follow‐up information was available, the estimated 5‐year overall survival rate was 51.6%; tumour size ≥5 cm was correlated significantly with shorter overall survival time ( P = 0.0016), while mitotic count (≥50 or ≥100 per 50 high‐power fields) proved to be no prognostic factor. Conclusions GI ‐ LMS s have distinctive clinicopathological and immunohistochemical features and exhibit aggressive biological behaviour.