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Immunohistopathological features of anaplastic large‐cell lymphoma according to anaplastic lymphoma kinase expression and bone marrow involvement pattern
Author(s) -
Park Sang Hyuk,
Chi HyunSook,
Cho YoungUk,
Jang Seongsoo,
Park ChanJeoung
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12141
Subject(s) - anaplastic lymphoma kinase , anaplastic large cell lymphoma , bone marrow , lymphoma , pathology , medicine , large cell lymphoma , immunohistochemistry , malignant pleural effusion , lung cancer
Aims The immunohistopathological features of lesions involving the bone marrow ( BM ) were examined in patients with anaplastic large‐cell lymphoma ( ALCL ) to identify the most useful markers for the detection of BM involvement in ALCL . Methods and results A total of 80 patients with ALCL were enrolled, of whom 15 (18.8%) showed BM involvement. Anaplastic lymphoma kinase‐negative ( ALK –) patients ( n = 11) showed a nodular BM involvement pattern more frequently than ALK + patients ( n = 4; 72.7% versus 25.0%, P = 0.095). Patients with interstitial BM involvement were more frequently ALK + than those with nodular BM involvement (50.0% versus 11.1%, P = 0.095). CD 30 positivity was the strongest indicator of the presence of BM lesions, regardless of the BM involvement pattern. The application of CD 30 in cases without morphological evidence of BM involvement detected subtle BM involvement by ALCL in 13.7% of cases, which were predominantly ALK +. Conclusions The immunohistopathological features of BM lesions in patients with ALCL differ according to ALK status and BM involvement pattern. CD 30 is the most useful marker for the identification of BM lesions in ALCL patients and should be employed in all ALCL patients without exception, especially ALK + cases.