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The clinical significance of mesenchyme forkhead 1 ( F ox C 2) in gastric carcinoma
Author(s) -
Zhu JinLiang,
Song YongXi,
Wang ZhenNing,
Gao Peng,
Wang MeiXian,
Dong YuLan,
Xing ChengZhong,
Xu HuiMian
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12132
Subject(s) - immunohistochemistry , mesenchyme , cancer , cancer research , epithelial–mesenchymal transition , pathology , metastasis , biology , medicine , epithelium
Aims Mesenchyme forkhead 1 ( F ox C 2) is an epithelial–mesenchymal transition ( EMT )‐inducing factor. Previous studies have demonstrated that F ox C 2 binds directly to the promoter region of p120‐catenin (p120ctn). The aim of this study was to investigate the clinical significance of F ox C 2 expression and the inter‐relationship between F ox C 2 and p120ctn, in gastric cancer. Methods and results Immunohistochemistry was used to examine the expression of F ox C 2 and p120ctn proteins in 325 gastric cancer samples. Staining for F ox C 2 in cancer tissues was markedly stronger than in normal tissues. High F ox C 2 expression was associated significantly with differentiation, invasion depth, lymph node metastasis and tumour stage. Patients with high F ox C 2 expression or low p120ctn expression had a poor prognosis. In the high p120ctn expression group, the prognosis for patients with low F ox C 2 expression was better than for the high F ox C 2 group. Moreover, stepwise C ox regression showed that p120ctn was an independent prognostic factor, but F ox C 2 in combination with p120ctn was not correlated significantly with survival. Conclusions We found that F ox C 2 and p120ctn play important roles in the progression and prognosis of gastric cancer. Moreover, F ox C 2 and p120ctn should be evaluated further as novel biomarkers and therapeutic targets for gastric cancer treatment.