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Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer
Author(s) -
Jardel Pauline,
Debiais Celine,
Godet Julie,
Irani Jacques,
Fromont Gaelle
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12129
Subject(s) - aromatase , prostate cancer , androgen receptor , immunohistochemistry , cancer research , biology , cancer , tissue microarray , androgen , hormonal therapy , breast cancer , endocrinology , medicine , pathology , hormone , immunology
Aims Ductal carcinoma ( DC ) of the prostate is an entity distinct from the common acinar cancer ( AC ), both on clinical and morphological aspects. We aimed to analyze the expression of molecules involved in either hormonal signalling or androgen independent pathways, in DC compared to high grade AC . Methods and results A tissue microarray was constructed with samples from 24 cases of DC and 27 cases of high grade AC. Immunohistochemistry was performed using antibodies directed against: Ki67; androgen receptor (AR); PSA; 5alpha‐reductase 1, 2, 3; oestrogen receptors alpha and beta (ERA and ERB); aromatase; Alpha keto reductase 1C3; Squalene epoxidase (SQLE); BCAR1; Src. Cell proliferation and ERB staining were significantly increased in DC compared to AC. In contrast, the expressions of enzymes SQLE, aromatase, and 5 alpha reductase 2, were higher in AC. Staining for BCAR1 and Src, markers associated with androgen‐independent pathways, was increased in DC compared to AC. These differences remained significant after adjusting for pTNM stage. Conclusions These results suggest that the hormone related molecular pathways that drive cancer progression might be different in AC and DC . The decrease in steroid synthesis related enzymes, together with up‐regulation of the BCAR 1‐Src pathway, emphasizes the biological particularities of DC .