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I g G 4‐related sialadenitis is rare: histopathological investigation of 129 cases of chronic submandibular sialadenitis
Author(s) -
Harrison John D,
RodriguezJusto Manuel
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12122
Subject(s) - sialadenitis , medicine , pathology , submandibular gland , dermatology , salivary gland
Aims The incidence of I g G 4‐related sialadenitis among cases of chronic sialadenitis is unknown, and so we investigated the presence of I g G 4 plasma cells in 129 specimens from an archival collection of consecutive cases of chronic submandibular sialadenitis collected from 1969 to 1989 that had been previously extensively characterized. Methods and results Immunohistology revealed that only three of the 129 specimens contained areas over the threshold for I g G 4‐related sialadenitis of 50 I g G 4 plasma cells per high‐power field, and these cells were part of a non‐specific chronic inflammatory infiltrate associated with ducts that had contained sialoliths. The infiltrate of I g G 4 plasma cells in the series was significantly positively related to the total infiltrate of inflammatory cells, fibrosis, atrophy, lymphoid germinal centres and sialoliths. Conclusions I g G 4‐related sialadenitis is rare and was not found in the present series. The I g G 4 plasma cells that were present in the glands were part of a non‐specific chronic inflammatory infiltrate.