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Clinical features and treatment of intracranial chordoid meningioma: a report of 30 cases
Author(s) -
Wang XiaoQiang,
Mei GuangHai,
Zhao Lin,
Li ShiTing,
Gong Ye,
Zhong Jun,
Chen Hong,
Jiang ChengChuan
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12113
Subject(s) - meningioma , medicine , univariate analysis , radiation therapy , resection , surgery , pathological , multivariate analysis
Aims To discuss the clinical characteristics and prognosis of chordoid meningioma ( CM ). Methods and results Tumour samples of CM from 30 patients were re‐examined. The postoperative outcomes were analyzed on the basis of clinical observations. The survival probabilities were calculated using the K aplan– M eier method. Thirty‐two operations were performed in 30 cases, including 27 operations for total removal and five operations for subtotal removal. The median follow‐up period was 34.0 months. Tumour recurred in five patients, with a median recurrence time of 32.0 months. No systemic manifestations of C astleman's syndrome were found. The majority (80%) of tumours were found in the supratentorial compartments. The MIB ‐1 labelling index ( MIB ‐1 LI ) varied from 1% to 10%. In univariate analyses, the presence of aggressive factors ( P = 0.001) and the extent of resection ( P = 0.037) were related to progression‐free survival ( PFS ). The MIB ‐1 LI ( P = 0.50) and postoperative radiotherapy ( P = 0.62) were not related to PFS . Conclusions Chordoid meningioma is a rare subtype of meningioma, and is often found supratentorially. There is an absence of association with C astleman's syndrome. Aggressive factors and the extent of resection are helpful in predicting recurrence. It might be more pertinent to downgrade CM to grade I , unless it shows aggressive factors.