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CD 117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
Author(s) -
Fan Huijie,
Yuan Yuan,
Wang Junsheng,
Zhou Fuyou,
Zhang Mingzhi,
Giercksky KarlErik,
Nesland Jahn M,
Suo Zhenhe
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12111
Subject(s) - stage (stratigraphy) , immunohistochemistry , tissue microarray , medicine , clinical significance , univariate analysis , metastasis , pathology , carcinoma , t stage , lymph node , gastroenterology , cancer , oncology , multivariate analysis , biology , paleontology
Aims To investigate the aberrant expression of CD 117 in oesophageal squamous cell carcinoma ( SCC ) and its prognostic significance.Methods and results Immunohistochemical staining for CD 117 was performed on tissue microarray and routine tissue sections from 157 oesophageal SCC patients and 10 normal oesophageal epithelia adjacent to tumour. The positive rate of CD 117 expression was 29.9% in oesophageal SCC tissues, whereas no CD 117 expression was detected in the 10 normal oesophageal epithelia. CD 117 expression was significantly associated with T stage ( P < 0.001), distant metastasis ( P = 0.015), lymph node metastasis ( P = 0.019), and clinical stage ( P = 0.021). Progression‐free survival in the patients with CD 117‐positive tumours was shorter than that in the patients with CD 117‐negative tumours ( P = 0.010). In univariate analyses, CD 117 expression was the most significant factor for overall survival of oesophageal SCC patients ( P < 0.001), followed by lymph node metastasis ( P = 0.001), T stage ( P = 0.002), clinical stage ( P = 0.006), distant metastasis ( P = 0.020), and histological grade ( P = 0.027). Multivariate analyses verified that CD 117 expression was an independent prognostic marker for oesophageal SCC patients ( P = 0.002). In addition, CD 117 expression predicted poorer survival in patients without distant metastases.Conclusions CD 117 expression in operable oesophageal SCC may be a valuable prognostic marker, and detection of its expression in clinical samples may be useful in defining a subclass of oesophageal SCC s with extremely poor clinical outcome, which may require a specially targeted treatment modality.