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Prognostic significance of heat shock proteins in urothelial carcinoma of the urinary bladder
Author(s) -
Yu HuiJung,
Chang YenHwa,
Pan ChinChen
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12087
Subject(s) - immunohistochemistry , bladder cancer , cystectomy , clinical significance , heat shock protein , urinary bladder , medicine , urinary system , urothelium , carcinoma , pathology , pathophysiology , cancer , oncology , cancer research , biology , biochemistry , gene
Aims Heat shock proteins ( HSP s) are a group of molecules induced by a variety of environmental and pathophysiological stresses, including cancer. The expression of HSP s has been implicated in the regulation of apoptosis and immunity in neoplasia. The purpose of this study was to evaluate the expression and clinicopathological relevance of several HSP s in urothelial carcinomas of the urinary bladder. Methods and results Immunohistochemical staining for HSP 27, HSP 60, HSP 70 and HSP 90 was performed on samples collected from 744 clinical cases. The results were correlated with clinicopathological characteristics using univariate and multivariate analyses. High expression of HSP 70 predicted recurrence of non‐muscle‐invasive urothelial carcinoma treated by transurethral resection, and low expression of HSP 27 correlated with progression and cancer‐specific mortality for non‐muscle‐invasive cancers treated by transurethral resection. Low expression of HSP 27 also predicted cancer‐specific mortality for patients who underwent cystectomy. Conclusions Both HSP 27 and HSP 70 impact on the biological behaviour of urothelial carcinomas of the urinary bladder. Immunohistochemical assessment of HSP s can provide useful prognostic information that could ultimately help to develop individualized surveillance programmes.