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Does the calcification of adamantinomatous craniopharyngioma resemble the calcium deposition of osteogenesis/odontogenesis?
Author(s) -
Songtao Qi,
Xiaorong Yan,
Jun Pan,
Yongjian Deng,
Jin Liang,
Guanglong Huang,
Yuntao Lu,
Jian Ruan,
Xiangzhao Li,
Jiaming Xu
Publication year - 2014
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12071
Subject(s) - calcification , craniopharyngioma , paracrine signalling , transdifferentiation , pathology , biology , bone morphogenetic protein 2 , anatomy , microbiology and biotechnology , chemistry , medicine , stem cell , endocrinology , biochemistry , receptor , in vitro
Aims Calcification in adamantinomatous craniopharyngioma ( ACP ) is troublesome for surgical intervention. The aim of this study was to examine the osteogenic proteins that play important roles in the calcium deposition of the odontogenic/osteogenic tissues in craniopharyngioma. Methods and results Craniopharyngiomas ( n = 89) were investigated for the presence and expression pattern of the osteoinductive/odontoinductive factor bone morphogenetic protein‐2 ( B mp2) and two osteoblastic differentiation makers, Runt‐related transcription factor‐2 ( R unx2) and O sterix, using immunohistochemistry and W estern blotting. Our results showed that B mp2, R unx2 and O sterix levels increased in cases with high calcification and correlated positively with the degree of calcification in ACP , whereas they showed little or no expression in squamous papillary craniopharyngioma. In ACP , B mp2 was expressed primarily in the stellate reticulum and whorl‐like array cells; R unx2 and O sterix tended to be expressed in calcification‐related epithelia, including whorl‐like array cells and epithelia in/around wet keratin and calcification lesions. Conclusions Our study indicated, for the first time, that osteogenic factor Bmp2 may play an important role in the calcification of ACP via autocrine or paracrine mechanisms. Given the presence of osteogenic markers ( R unx2 and O sterix), craniopharyngioma cells could differentiate into an osteoblast‐like lineage, and the process of craniopharyngioma calcification resembles that which occurs in osteogenesis/odontogenesis.