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Molecular abnormalities in ovarian carcinoma: clinical, morphological and therapeutic correlates
Author(s) -
Gurung Ananta,
Hung Tawny,
Morin Jason,
Gilks C Blake
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12033
Subject(s) - pathological , serous fluid , ovarian carcinoma , clear cell carcinoma , carcinogenesis , clear cell , pathology , carcinoma , serous carcinoma , ovarian cancer , mucinous carcinoma , cystadenocarcinoma , biology , medicine , oncology , cancer , adenocarcinoma
The histopathological classification of ovarian surface epithelial carcinomas (referred to hereafter as ‘ovarian carcinoma’) has shifted over the past 10 years to reflect more clearly our understanding of molecular events during carcinogenesis. Ovarian carcinoma is no longer viewed as a single entity but as multiple disease processes, with each having different molecular pathways altered during oncogenesis, resulting in differences in clinical and pathological features, such as biomarker expression, pattern of spread and response to chemotherapy. There are five subtypes of ovarian carcinoma that are sufficiently distinct and well‐characterized that they should be considered to be different diseases, i.e. high‐grade serous, clear cell, endometrioid, mucinous and low‐grade serous, from most to least common, respectively. This review summarizes the molecular abnormalities of these five ovarian carcinoma subtypes, relating them to clinical and pathological features.