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Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells
Author(s) -
Li Lei,
Othman Mohammad,
Rashid Asif,
Wang Hua,
Li Zhaoshen,
Katz Matthew H,
Lee Jeffrey E,
Pisters Peter W,
Abbruzzese James L,
Fleming Jason B,
Wang Huamin
Publication year - 2013
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/his.12023
Subject(s) - pathology , chromogranin a , cytokeratin , giant cell , synaptophysin , vimentin , immunohistochemistry , eosinophilic , pancreas , neoplasm , proliferative index , medicine
Aims Solid pseudopapillary neoplasm of the pancreas ( SPN ) is a rare low‐grade malignant neoplasm. To our knowledge, SPN with prominent atypical multinucleated giant tumour cells ( MNGTC s) has not yet been reported. Methods and results We identified four cases of SPN with prominent atypical MNGTC s in a cohort of 62 cases of SPN (6.5%). The MNGTC s contained multiple enlarged, hyperchromatic, irregular nuclei with ample eosinophilic cytoplasm, typically present in the solid area of the tumour. The MNGTC s had an immunohistochemical profile typical of the conventional SPN and were positive for vimentin, β‐catenin, CD 10 and progesterone receptor, but negative for pan‐cytokeratin, chromogranin, synaptophysin, trypsin, Ki‐67 and CD 68 in all four cases. Patients of SPN with prominent MNGTC s were older than those with conventional SPN ( P = 0.01); tumours were discovered incidentally by imaging studies for an unrelated disease in all four cases, and with a female to male ratio of 1:1. The proliferation index (Ki‐67) was <1% in all four cases. None of the three patients for whom information was available developed recurrence during follow‐up of 2.7, 3.8 and 5.0 years. Conclusions The presence of MNGTC s in SPN most probably represents degenerative change of the tumour cells and does not seem to affect the prognosis.