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Severity of liver fibrosis using shear wave elastography is influenced by hepatic necroinflammation in chronic hepatitis patients, but not in cirrhotic patients
Author(s) -
Nakano Chikage,
Nishimura Takashi,
Tada Toshifumi,
Yoshida Masahiro,
Takashima Tomoyuki,
Aizawa Nobuhiro,
Ikeda Naoto,
Nishikawa Hiroki,
Enomoto Hirayuki,
Hatano Etsuro,
Yano Hirohisa,
Hirota Seiichi,
Hachiya Hiroyuki,
Iijima Hiroko
Publication year - 2021
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13617
Subject(s) - medicine , transient elastography , liver biopsy , gastroenterology , elastography , fibrosis , inflammation , biopsy , ultrasound , pathology , radiology
Aim Shear wave elastography (SWE) in patients with chronic liver diseases is a noninvasive useful method for the diagnosis of liver fibrosis severity, which can be an alternative to liver biopsy. However, the liver stiffness measurement using SWE can be affected by various factors including hepatic inflammation, extrahepatic cholestasis, heart failure, and underlying liver diseases. The aim of this study is to clarify the correlation between liver stiffness using SWE and hepatic necroinflammation serologically and pathologically. Methods A total of 843 patients with chronic liver disease who received liver biopsy were analyzed. Liver stiffness measurement using transient elastography (TE) and virtual touch quantification (VTQ) were carried out on the same day as the liver biopsy. The correlation between SWE and hepatic inflammation was analyzed serologically and pathologically. Results The liver stiffness values increased significantly with the progression of liver fibrosis and inflammation (overall p < 0.001). In patients with F0–1, F2, and F3, TE and VTQ values of A2 or A3 were significantly higher than those of A0 or A1 ( p value, all <0.05), but not in patients with F4. The median alanine aminotransferase (ALT) values increased significantly with the progression of liver inflammation ( p < 0.001). Moreover, TE and VTQ in patients with ALT ≥70 IU/L were significantly higher than those in patients with ALT <70 IU/L ( p < 0.01), but not in patients with F4. Conclusion Shear wave elastography can be affected by hepatic necroinflammation in F0–F3 fibrosis, but not in F4.