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Attenuation imaging based on ultrasound technology for assessment of hepatic steatosis: A comparison with magnetic resonance imaging‐determined proton density fat fraction
Author(s) -
Tada Toshifumi,
Kumada Takashi,
Toyoda Hidenori,
Nakamura Shinichiro,
Shibata Yusuke,
Yasuda Satoshi,
Watanuki Yutaka,
Tsujii Kazuyuki,
Fukuda Naoya,
Fujioka Mamoru,
Takeshima Kenji,
Niwa Fumihiko,
Ogawa Sadanobu,
Hashinokuchi Shinichi,
Kataoka Saki,
Ichikawa Hironori,
Iijima Hiroko
Publication year - 2020
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13563
Subject(s) - steatosis , magnetic resonance imaging , medicine , confidence interval , liver steatosis , ultrasound , receiver operating characteristic , nuclear medicine , fatty liver , attenuation , gastroenterology , radiology , physics , disease , optics
Aim A new method has recently been developed for diagnosing hepatic steatosis based on attenuation measurement using ultrasound. We investigated the ability of attenuation imaging (ATI) to detect steatosis that was identified by proton density fat fraction (PDFF) on magnetic resonance imaging (MRI) in patients with chronic liver disease. Methods A total of 119 patients with chronic liver disease (non‐B, non‐C) were analyzed. The relationship between ATI values and steatosis grades determined by PDFF was evaluated. Additionally, the diagnostic ability of ATI was evaluated using receiver operating characteristic curve analysis, and the correlation between ATI values and PDFF values was determined. Results The ATI values of steatosis grades 0, 1, 2, and 3 were 0.55, 0.61, 0.74, and 0.84 dB/cm/MHz, respectively ( P < 0.001). There was a statistically significant trend of higher ATI values with higher steatosis grades ( P < 0.001). The correlation coefficient ( r ) between PDFF values and ATI values was 0.70 (95% confidence interval [CI] 0.59–0.78; P < 0.001), corresponding to a strong relationship. The diagnostic ability of ATI for steatosis grades ≥1, ≥2, and 3, as determined by PDFF, were 0.81 (95% CI 0.73–0.89), 0.87 (95% CI 0.79–0.96), and 0.94 (95% CI 0.89–0.98), respectively. The r between PDFF values and ATI values was 0.49 (95% CI 0.31–0.63; P < 0.001) for patients with mild or no steatosis (grade ≤1), and 0.75 (95% CI 0.57–0.86; P < 0.001) for obese patients (body mass index ≥25 kg/m 2 ). Conclusion ATI values had an excellent diagnostic ability to detect hepatic steatosis.