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Prevalence and characteristics of portopulmonary hypertension in cirrhotic patients who underwent both hepatic vein and pulmonary artery catheterization
Author(s) -
Atsukawa Masanori,
Tsubota Akihito,
Hatano Masaru,
Kondo Chisa,
Shioda Kaori,
Ohno Hiroki,
Kawano Tadamichi,
Hayama Korenobu,
Arai Taeang,
NakagawaIwashita Ai,
Itokawa Norio,
Kaneko Keiko,
Yoshida Yuji,
Koeda Mai,
Okubo Tomomi,
Yamamoto Teppei,
Yamamoto Takeshi,
Taniai Nobuhiko,
Yoshida Hiroshi,
Kanazawa Hidenori,
Shimizu Wataru,
Iwakiri Katsuhiko
Publication year - 2020
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13560
Subject(s) - portopulmonary hypertension , medicine , portal hypertension , pulmonary wedge pressure , portal venous pressure , cirrhosis , pulmonary artery , cardiology , primary biliary cirrhosis , pulmonary hypertension , vascular resistance , hemodynamics , gastroenterology
Aim Portopulmonary hypertension (PoPH) is a well‐known complication of liver cirrhosis. The aim of this study was to clarify the pulmonary hemodynamics and the prevalence and characteristics of PoPH in patients with portal hypertension. Methods The subjects were 335 patients with portal hypertension diagnosed by hepatic vein pressure gradient (HVPG). Among them, 186 patients received measurements of pulmonary artery pressure (PAP), pulmonary artery wedge pressure (PAWP) and pulmonary vascular resistance (PVR). PoPH was diagnosed by PAP >20 mmHg, PVR ≥3 Wood units (WU) and PAWP ≤15 mmHg. Results The Child–Pugh classification was class A in 53, B in 92 and C in 41 patients. Median (range) values of HVPG, PAP, PVR and PAWP were 18.4 (5.5–39.0) mmHg, 12.9 (6.6–40.8) mmHg, 0.8 (0.1–4.5) WU and 7.5 (2.2–15.4) mmHg, respectively. Of six patients with PAP >20 mmHg, four had autoimmune hepatitis or primary biliary cholangitis, with the prevalence being significantly higher than that in patients with PAP ≤20 mmHg. Meanwhile, no significant difference was noted in the hepatic functional reserve or HVPG between patients with PAP >20 mmHg and ≤20 mmHg. Only two patients met the diagnostic criteria of PoPH and both patients were Child–Pugh B. The Child–Pugh score and HVPG were not associated with PoPH. Conclusions Our study demonstrated that only two patients were complicated by PoPH. High PAP values were noted in patients with primary biliary cholangitis or autoimmune hepatitis. However, the presence of PoPH and high PAP were not associated with the degree of hepatic functional reserve or HVPG.