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Diagnostic accuracy of FibroScan‐AST score to identify non‐alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non‐alcoholic fatty liver disease: Comparison between M and XL probes
Author(s) -
Oeda Satoshi,
Takahashi Hirokazu,
Imajo Kento,
Seko Yuya,
Kobayashi Takashi,
Ogawa Yuji,
Moriguchi Michihisa,
Yoneda Masato,
Anzai Keizo,
Irie Hiroyuki,
Sueoka Eisaburo,
Aishima Shinichi,
Kage Masayoshi,
Itoh Yoshito,
Eguchi Yuichiro,
Nakajima Atsushi
Publication year - 2020
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13508
Subject(s) - steatohepatitis , fatty liver , gastroenterology , medicine , alcoholic liver disease , alcoholic fatty liver , disease , cirrhosis
Aim Recently, FibroScan‐AST (FAST) score was reported to be effective for identifying non‐alcoholic steatohepatitis (NASH) with significant activity and fibrosis in non‐alcoholic fatty liver disease (NAFLD). The aim of this study was to confirm the diagnostic accuracy of FAST score of Japanese patients and compare the cut‐off values and diagnostic accuracy between the FibroScan M and XL probes. Methods Eighty‐two and 84 patients were included the verification and validation sets, respectively. All patients were diagnosed with NAFLD by biopsy by two central expert pathologists. Liver stiffness measurements and controlled attenuation parameter were carried out, and diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Results No significant difference existed in FAST score between the M and XL probes (0.489 vs. 0.483, P = 0.187). No significant difference existed in the area under the ROC between the two probes (M, 0.7598; XL, 0.7614; P = 0.958). According to the Youden index, the cut‐off value using the M probe was 0.57 with 68.2% sensitivity and 78.3% specificity. For the XL probe, the cut‐off value was 0.56 with 68.2% sensitivity and 73.3% specificity. To obtain sensitivity and specificity values higher than 90%, cut‐off values of 0.35 and 0.66 were chosen for the M probe and 0.32 and 0.63 were chosen for the XL probe. Conclusions There was no significant difference in diagnostic accuracy of FAST score between the FibroScan M and XL probes. The FAST score can be used to identify NASH with significant risk in Japanese patients regardless of probe selection.