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Glecaprevir and pibrentasvir for Japanese patients with chronic hepatitis C genotype 1 or 2 infection: Results from a multicenter, real‐world cohort study
Author(s) -
Ogawa Eiichi,
Furusyo Norihiro,
Nakamuta Makoto,
Nomura Hideyuki,
Satoh Takeaki,
Takahashi Kazuhiro,
Koyanagi Toshimasa,
Kajiwara Eiji,
Dohmen Kazufumi,
Kawano Akira,
Ooho Aritsune,
Azuma Koichi,
Kato Masaki,
Shimoda Shinji,
Hayashi Jun
Publication year - 2019
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13328
Subject(s) - medicine , cohort , genotype , chronic hepatitis , cohort study , virology , biology , virus , biochemistry , gene
Aim Glecaprevir (GLE) and pibrentasvir (PIB) are new direct‐acting antiviral agents (DAAs) with pangenotypic inhibitors that respectively target the hepatitis C virus (HCV) NS3/4 protease and NS5A. The aim of this study was to evaluate the effectiveness and safety of combining GLE and PIB for patients with HCV genotype (GT) 1 or 2 infection in the clinical setting, including patients DAA‐experienced or on hemodialysis. Methods This multicenter, real‐world, retrospective, cohort study consisted of 314 Japanese patients who were treated with GLE (300 mg) and PIB (120 mg) for a fixed 8‐ or 12‐week duration. We evaluated the sustained virologic response rate 12 weeks after the end of treatment (SVR12) and adverse events. Results Among the treated patients, 122 had GT1 and 192 GT2 infection. The overall SVR12 rates in the per‐protocol populations were 99.2% (119/120) for GT1 and 98.9% (183/185) for GT2. High SVR12 rates were observed in almost all subgroups, including cirrhosis, receiving hemodialysis, or previous all‐oral DAA groups treated with asunaprevir and daclatasvir (GT1b), ledipasvir/sofosbuvir (GT1), or sofosbuvir and ribavirin (GT2). Virological relapse occurred in only 1.0% (3/305) of the patients who completed treatment. The most common adverse events were pruritus and fatigue (>5% of patients). Serious adverse events were rare and discontinuation due to an adverse event was required for 1.6% of the patients. Conclusions In this real‐world cohort study, treatment with GLE/PIB achieved high SVR12 rates with a low rate of serious adverse events among patients with HCV GT1 or 2 infection.