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Risk factors for loss of skeletal muscle mass in patients with cirrhosis
Author(s) -
Sung Ji Hyun,
Uojima Haruki,
Hidaka Hisashi,
Tanaka Yoshiaki,
Wada Naohisa,
Kubota Kousuke,
Nakazawa Takahide,
Shibuya Akitaka,
Fujikawa Tomoaki,
Yamanoue Hiroki,
Kako Makoto,
Koizumi Wasaburo
Publication year - 2019
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13308
Subject(s) - medicine , cirrhosis , hepatic encephalopathy , gastroenterology , confidence interval , odds ratio , skeletal muscle , prospective cohort study
Aim The present study aimed to assess the correlation between loss of skeletal muscle mass (LSMM) and the clinical characteristics of patients with liver cirrhosis. Methods This multicenter, prospective study was undertaken at five locations in Japan and involved a 12‐month observation period. After baseline assessment, the change in the skeletal muscle index per year (ΔSMI/y) was evaluated in the enrolled patients; LSMM was defined as ΔSMI/y < 0. We evaluated the relationships between LSMM and baseline clinical characteristics in patients with liver cirrhosis. Results A total of 166 patients with cirrhosis were enrolled and, of these, 123 patients (74.1%) showed LSMM. Multivariate analysis confirmed that hepatic encephalopathy, Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA + ‐M2BP) (≥1.86), age (≥60 years), and grip strength (<18 kg for women and <26 kg for men) were independent predictors of skeletal muscle decline ( P = 0.042, odds ratio [OR] 8.997, 95% confidence interval [CI] 1.083–74.71; P = 0.023, OR 3.970, 95% CI 1.468–6.177; P = 0.037, OR 2.526, 95% CI 1.056–6.045; and P = 0.002, OR 3.970, 95% CI 1.691–9.322, respectively). Conclusions Advanced age, low grip strength, hepatic encephalopathy, and high WFA + ‐M2BP might be risk factors for LSMM in liver cirrhosis patients.