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Comparison of hepatic arterial infusion chemotherapy between 5‐fluorouracil‐based continuous infusion chemotherapy and low‐dose cisplatin monotherapy for advanced hepatocellular carcinoma
Author(s) -
Kawaoka Tomokazu,
Aikata Hiroshi,
Kobayashi Tomoki,
Uchikawa Shinsuke,
Ohya Kazuki,
Kodama Kenichiro,
Nishida Yuno,
Daijo Kana,
Osawa Mitsutaka,
Teraoka Yuji,
Inagaki Yuki,
Honda Fumi,
Hatooka Masahiro,
Morio Kei,
Morio Reona,
Fujino Hatsue,
Nakahara Takashi,
Murakami Eisuke,
Tsuge Masataka,
Hiramatsu Akira,
Imamura Michio,
Kawakami Yoshiiku,
Baba Yasutaka,
Awai Kazuo,
Chayama Kazuaki
Publication year - 2018
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13232
Subject(s) - medicine , fluorouracil , hepatocellular carcinoma , cisplatin , chemotherapy , regimen , gastroenterology , adverse effect , propensity score matching
Aim The aim of this study is to compare the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) between 5‐fluorouracil (5‐FU)‐based continuous infusion chemotherapy and low‐dose cisplatin (CDDP) monotherapy in patients with advanced hepatocellular carcinoma (HCC). Methods Patients were grouped according to HAIC regimen (5‐FU group, n = 317/CDDP group, n = 66). A two‐to‐one match was created using propensity score analysis (5‐FU group, n = 102/CDDP group, n = 51). After matching, response rate (RR) and adverse events as primary end‐points, and survival and progression‐free survival as secondary end‐points, were analyzed. Results In the analysis of primary end‐points, the RR in the 5‐FU group was significantly higher than in the CDDP group (32.4% vs. 15.7%, P = 0.033). In patients with a Child–Pugh (CP) score of 5–7, the RR in the 5‐FU group was significantly higher than that in the CDDP group (36.1% vs. 15.4%, P = 0.020). In those with a CP score of 8–9, there was no significant difference in RR between the two groups (15.8% vs. 16.6%, P = 1.000). The reservoir system‐related complications were 9.8% in the 5‐FU group, and there was no significant difference in the incidence of grade 3/4 adverse events between the two matched groups ( P > 0.05). In terms of secondary end‐points, the median survival time was 9.1 and 8.7 months for the 5‐FU and CDDP groups, respectively ( P = 0.4917). Progression‐free survival was 3.9 months for the 5‐FU group and 4.9 months for the CDDP group ( P = 0.4). Conclusions 5‐Fluorouracil‐based continuous infusion chemotherapy could be suitable for advanced HCC patients with a CP score of 5–7 considering the treatment response.