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Steroidogenesis in ovarian‐like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms
Author(s) -
Kumata Hiroyuki,
Murakami Keigo,
Ishida Kazuyuki,
Miyagi Shigehito,
Arakawa Atsushi,
Inayama Yoshiaki,
Kinowaki Keiichi,
Ochiai Atsushi,
Kojima Motohiro,
Higashi Michiyo,
Moritani Suzuko,
Kuwahara Kyoko,
Nakatani Yukio,
Kajiura Dai,
Tamura Gen,
Kijima Hiroshi,
Yamakawa Mitsunori,
Shiraishi Taizo,
Inadome Yukinori,
Murakami Kazuhiro,
Suzuki Hiroyoshi,
Sawai Takashi,
Unno Michiaki,
Kamei Takashi,
Sasano Hironobu
Publication year - 2018
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.13201
Subject(s) - stroma , medicine , mesenchymal stem cell , pathology , cancer research , ovary , oncology , immunohistochemistry
Steroidogenesis in hepatic mucinous cystic neoplasm Aim Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas, and retroperitoneum but very rarely in the liver. Mucinous cystic neoplasms are known to harbor ovarian‐like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. In this study we evaluated steroidogenesis in OLS of 25 hepatic MCNs and 24 pancreatic MCNs. Methods Both steroid receptors and steroidogenic factors were immunohistochemically evaluated using H‐scores and results were compared with those in 15 ovarian MCNs and 10 normal ovaries. Results Androgen receptor (AR) H‐scores in OLS were significantly higher in hepatic, pancreatic, and ovarian MCN than those in normal ovaries. H‐scores of cytochrome P450 17α‐hydroxylase/c17–20 lyase (P450c17) and 5α‐reductase‐1 (5αRED‐1) in the stroma were significantly higher in OLS of hepatic and pancreatic MCN than in the stroma of ovarian MCN and normal ovary. In tumor epithelium, AR H‐scores were significantly higher in hepatic and pancreatic MCN than in ovarian MCN. In both hepatic and pancreatic MCN, a significant positive correlation was detected between AR H‐score in the epithelium and P450c17 H‐score in OLS (hepatic MCN: Pearson's r = 0.446, P = 0.025; pancreatic MCN: r = 0.432, P = 0.035). In pancreatic MCN, a significantly positive correlation was detected between AR H‐score in the tumor epithelium and 5αRED‐1 H‐score in OLS (Pearson's r = 0.458, P = 0.024). Conclusions These results indicated that locally produced androgens in OLS could be pivotal for tumorigenesis of both hepatic and pancreatic MCN and influence epithelial cells, possibly in a paracrine fashion, which could represent biological significance of OLS in these neoplasms.