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Use of finger‐piece method for indocyanine green clearance test
Author(s) -
Sagawa Eri,
Okubo Hironao,
Sorin Yushi,
Nakadera Eisuke,
Fukada Hiroo,
Igusa Yuki,
Kokubu Shigehiro,
Miyazaki Akihisa,
Watanobe Ikuo,
Sugo Hiroyuki,
Kojima Kuniaki,
Watanabe Sumio
Publication year - 2017
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12858
Subject(s) - indocyanine green , medicine , blood sampling , liver function , nuclear medicine , significant difference , liver disease , surgery , gastroenterology
Aim The indocyanine green (ICG) finger‐piece method (FPM), which allows measurement of the ICG concentration by mounting a light sensor onto a finger, is used to assess liver function. We compared the ICG FPM with the conventional ICG blood sampling method (BSM) in patients with liver disorders. Methods Ninety consecutive patients simultaneously underwent the ICG BSM and ICG FPM. After ICG administration, blood samples were collected at 5, 10, and 15 min for the ICG BSM. The ICG concentration was measured through the finger piece by an ICG clearance meter. Results Seventy‐one patients (78.9%) had Child–Pugh class A liver disease, and 19 (21.1%) had class B or C. The FPM‐measured ICG plasma disappearance rate was positively correlated with the BSM‐measured values ( r = 0.886, P < 0.001). Bland–Altman analysis showed good agreement between the two methods (mean difference, 0.012 ± 0.018). The FPM‐measured ICG plasma disappearance rate was positively correlated with the BSM‐measured values both in patients with Child–Pugh class A liver disease ( r = 0.821, P < 0.001) and class B or C liver disease ( r = 0.859, P < 0.001). Conclusion The ICG FPM may be an alternative to the ICG BSM for liver function assessment.