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Pathological Findings of NASH and NAFLD
Author(s) -
Kathryn Effendi,
Kenichi Harada,
Etsuko Hashimoto,
Masayoshi Kage,
Kazuhiko Koike,
Fukuo Kondo,
Masayuki Nakano,
Hidenori Ojima,
Takeshi Okanoue,
Michiie Sakamoto,
Yoshio Sumida,
Hanako Tsujikawa,
Gotaro Yamada,
Yoh Zen
Publication year - 2017
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12847
Subject(s) - nonalcoholic fatty liver disease , fatty liver , medicine , steatosis , fibrosis , steatohepatitis , hepatology , nonalcoholic steatohepatitis , pathological , gastroenterology , disease , pathology
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common chronic liver disease worldwide. NAFLD comprises a variety of clinical and histopathological changes that can be broadly divided into nonalcoholic fatty liver (NAFL, simple steatosis) and nonalcoholic steatohepatitis (NASH). The differential diagnosis between NAFL and NASH is important because NASH is a more advanced form. This diagnosis therefore determines the prognosis and therapeutic management. At present the interpretation of NASH is made based on the histopathological features of steatohepatitis, i.e. ‘steatosis’, ‘lobular inflammation’, hepatocyte ‘ballooning, ‘Mallory‐Denk bodies’ and ‘fibrosis’. Here, we summarize the pathological findings guidelines for NASH as it was already published in 2015 in Japanese in the clinical guidebook organized by the Japan Society of Hepatology.