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HLA‐DQ gene polymorphisms are associated with hepatocellular carcinoma and hepatitis B surface antigen in chronic hepatitis B virus infection
Author(s) -
Ochi Yuka,
Hashimoto Senju,
Kawabe Naoto,
Murao Michihito,
Nakano Takuji,
Kan Toshiki,
Nakaoka Kazunori,
Ohki Masashi,
Kurashita Takamitsu,
Takamura Tomoki,
Nomura Sayuri,
Nishikawa Toru,
Fukui Aiko,
Osakabe Keisuke,
Ichino Naohiro,
Yoshioka Kentaro
Publication year - 2017
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12812
Subject(s) - hbsag , hepatocellular carcinoma , genotype , hepatitis b virus , hbeag , single nucleotide polymorphism , medicine , virology , hepatitis b , immunology , virus , biology , gene , genetics
Aim Genome‐wide association studies have revealed that single nucleotide polymorphism (SNP) of human leukocyte antigen ( HLA)‐DQ is associated with the clearance of hepatitis B surface antigen (HBsAg) in acute hepatitis B virus (HBV) infection. We examined the effects of SNPs on the development of hepatocellular carcinoma (HCC) and markers of HBV in chronic HBV infection. Methods The SNPs of HLA‐DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV infection. Results In 224 hepatitis B e antigen (HBeAg)‐negative patients, those with rs2856718 genotype AG + GG had significantly lower hepatitis B core‐related antigen levels ( P = 0.0184), less frequent treatment with nucleotide/nucleoside analogs (NAs) ( P = 0.0433), and less frequent HCC development ( P = 0.0256) than those with genotype AA. Multivariate analysis selected age ( P = 0.0460), platelet count ( P = 0.0481), γ‐glutamyl transpeptidase ( P = 0.0030), and nucleotide/nucleoside analog treatment ( P = 0.0003) as factors independently associated with HCC development. HBeAg‐negative patients with rs7453920 genotype GG had significantly lower HBsAg levels ( P < 0.0001), a higher prevalence of HBV genotype C ( P = 0.0063), and a lower prevalence of the wild‐type basal core promoter region ( P = 0.0045) than those with genotype AA + AG. Multivariate analysis selected age ( P < 0.0001), platelet count ( P = 0.0021), HBV DNA levels ( P = 0.0314), wild type of precore region ( P = 0.0015), and rs7453920 ( P < 0.0001) as factors independently associated with HBsAg levels. Conclusion This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels.