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Pathogenesis of alcoholic liver disease
Author(s) -
Sugimoto Kazushi,
Takei Yoshiyuki
Publication year - 2017
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12736
Subject(s) - steatohepatitis , alcoholic liver disease , pathogenesis , cirrhosis , steatosis , insulin resistance , medicine , hepatocellular carcinoma , fatty liver , adipokine , fibrosis , liver disease , disease , bioinformatics , pathology , biology , obesity
Alcoholic liver disease (ALD) has become one of the most critical health problems in many countries, including Japan. Liver injury in ALD ranges from steatosis and steatohepatitis to fibrosis, cirrhosis, and hepatocellular carcinoma. Many factors are thought to contribute to the development and progression of ALD, particularly insulin resistance, generation of reactive oxygen species during alcohol metabolism, adipokines from visceral adipose tissue, and endotoxin derived from the gut. Although the pathogenesis of ALD has been widely investigated, the precise mechanisms are yet to be elucidated and many questions remain. This article reviews the possible mechanisms for the development of ALD identified to date.