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Clinical characteristics and survival outcomes of super‐elderly hepatocellular carcinoma patients not indicated for surgical resection
Author(s) -
Kinoshita Akiyoshi,
Onoda Hiroshi,
Ueda Kaoru,
Imai Nami,
Iwaku Akira,
Tanaka Ken,
Fushiya Nao,
Koike Kazuhiko,
Nishino Hirokazu,
Tajiri Hisao
Publication year - 2016
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12514
Subject(s) - hepatocellular carcinoma , medicine , surgical resection , resection , overall survival , oncology , general surgery , surgery
Aim Considering the dramatic increase in average life expectancy during the 20th century throughout the world, the management of elderly patients with cancer has become a global issue. We herein investigated the clinical characteristics and outcomes of super‐elderly hepatocellular carcinoma (HCC) patients over 80 years old not indicated for surgical resection. Methods We retrospectively evaluated 206 newly diagnosed HCC patients. The patients were divided into two groups according to their age at inclusion; a super‐elderly group (n = 37, ≥80 years) and a younger group (n = 169, <80 years). We compared the clinical characteristics, overall survival (OS) and disease‐specific survival (DSS) rates among the two groups. Both univariate and multivariate analyses were performed to identify the factors associated with the OS and DSS. Results The proportion of women was higher in the super‐elderly group than in the younger group (P = 0.017). There were no significant differences in the OS (P = 0.171) or DSS (P = 0.176) between the two groups. The multivariate analysis revealed that only the Cancer Liver Italian Program score (hazard ratio [HR], 2.972; P < 0.0001; HR, 3.694; P < 0.0001) was independently associated with the OS and DSS. Age was not found to be associated with the OS or DSS according to either the univariate or multivariate analysis. Conclusion There were no significant differences in the OS and DSS rates among the super‐elderly HCC patients and younger HCC patients not indicated for surgical resection. An advanced age itself does not restrict the therapeutic approach, even in super‐elderly HCC patients not indicated for surgical resection.