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Statin use and risk of gallstone disease: A meta‐analysis
Author(s) -
Kan HePing,
Guo Wenbin,
Tan YongFa,
Zhou Jie,
Liu Cundong,
Huang YuQi
Publication year - 2015
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12433
Subject(s) - medicine , statin , odds ratio , gallstones , confidence interval , meta analysis , cholecystectomy , gallbladder disease , disease , population , gastroenterology , case control study , cohort study , environmental health
Aim There is emerging evidence from animal and human studies that current statins can decrease the formation of gallbladder cholesterol gallstones and subsequently decrease the risk of gallstone disease, but consistent results have not been reported. We performed a meta‐analysis to provide an overview of the relevant studies. Methods Relevant studies published between J anuary 1980 and F ebruary 2014 were identified by searching M edline, E mbase and the C ochrane L ibrary. Studies were selected using a priori defined criteria. The strength of the relationship between statin use and risk of gallstone disease was assessed by adjusted odds ratio ( OR ). Results A total of 622 868 participants from six studies (four case–control studies, one cohort study and one cross‐sectional study) were identified in this meta‐analysis. The studies provided adjusted overall OR estimates for current statin use versus non‐use, leading to a pooled OR of 0.86 (95% confidence interval [ CI ], 0.77–0.97; P < 0.001). The overall OR of population‐based case–control studies and cholecystectomy due to gallstone disease were 0.83 (95% CI , 0.73–0.95; P = 0.0131) and 0.78 (95% CI , 0.74–0.82; P = 0.615), respectively. Conclusion There is evidence that current statin use lowers the risk of gallstone disease compared with non‐use, especially for cholecystectomy due to gallstone disease. Low statin use (1–4 prescriptions) did not decrease the risk of gallstone disease, but moderate and high statin use significantly decreased the risk. Further multicenter and better controlled studies are needed to confirm these findings.