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Prevalence and risk factors of obesity, hypertension, dyslipidemia and diabetes mellitus before and after adult living donor liver transplantation
Author(s) -
Hara Yasuyuki,
Kawagishi Naoki,
Nakanishi Wataru,
Tokodai Kazuaki,
Nakanishi Chikashi,
Miyagi Shigehito,
Ohuchi Noriaki
Publication year - 2015
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12418
Subject(s) - dyslipidemia , medicine , transplantation , liver transplantation , diabetes mellitus , gastroenterology , incidence (geometry) , tacrolimus , body mass index , risk factor , obesity , univariate analysis , cirrhosis , endocrinology , multivariate analysis , physics , optics
Aim The development of metabolic abnormalities after liver transplantation ( LTx ) contributes to cardiovascular events and mortality. We analyzed the prevalence and risk factors of obesity, hypertension, dyslipidemia and diabetes mellitus ( DM ) after adult living donor liver transplantation. Methods Fifty‐four adult recipients with a minimum follow up of 6 months receiving living donor liver transplantation between 2001 and 2012 at the T ohoku U niversity H ospital were retrospectively analyzed. Results The prevalence of hypertension increased from 18.5% before transplantation to 35.2% post‐transplantation, and new‐onset hypertension after transplantation was 57.9% of post‐transplant hypertension. Univariate analysis showed that risk factors of post‐transplant hypertension were age (>50 years, P = 0.0023), pretransplant body mass index ( BMI ) of 25 or more ( P = 0.0123), pretransplant hypertension ( P = 0.0012) and cyclosporin A (61.5% vs tacrolimus 25.0%, P = 0.0248). The incidence of obesity, dyslipidemia and DM did not change from before to after transplantation. LTx was curative in 77.8% of cases of pretransplant dyslipidemia and 20% of cases of pretransplant DM . Primary biliary cirrhosis cases comprised 85.7% of cases of pretransplant dyslipidemia that were cured by LTx . In univariate analysis, pretransplant BMI of 25 or more was the only risk factor of post‐transplant dyslipidemia ( P = 0.0098). The incidence of new‐onset DM after transplantation was 20%. Risk factors of post‐transplant DM were male sex ( P = 0.0156), pretransplant DM ( P < 0.0001), alcohol abuse ( P = 0.0248) and mycophenolate mofetil ( P = 0.0181) by univariate analysis. Conclusion The prevalence of hypertension increased after LTx and pretransplant obesity was associated with several post‐transplant metabolic abnormalities.