Premium
Liver stiffness measured by acoustic radiation force impulse elastography reflects the severity of liver damage and prognosis in patients with acute liver failure
Author(s) -
Kuroda Hidekatsu,
Kakisaka Keisuke,
Oikawa Takayoshi,
Onodera Mio,
Miyamoto Yasuhiro,
Sawara Kei,
Endo Ryujin,
Suzuki Kazuyuki,
Takikawa Yasuhiro
Publication year - 2015
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12389
Subject(s) - medicine , magnetic resonance elastography , elastography , receiver operating characteristic , acoustic radiation force , gastroenterology , hepatic encephalopathy , cirrhosis , radiology , ultrasound
Aim We measured liver stiffness ( LS ) in patients with acute liver failure ( ALF ) using acoustic radiation force impulse ( ARFI ) elastography and investigated the usefulness of measuring LS for predicting the prognosis of ALF patients. Methods From A pril 2010 to D ecember 2013, we evaluated 63 patients with acute liver disease. The subjects included 41 patients with acute hepatitis ( AH ), 16 patients with severe AH ( SAH ), who had no hepatic encephalopathy despite plasma prothrombin time of 40% or less, and six patients with fulminant hepatitis ( FH ) diagnosed according to the criteria of the J apanese S tudy G roup. The relationships among shear wave velocity ( SWV ), clinical diagnosis, liver function tests and prognosis were evaluated. Receiver–operator curve ( ROC ) analysis was performed to investigate whether ARFI elastography exhibits potential usefulness for the prediction of FH .Results The mean SWV on admission were 1.98 ± 0.55, 2.61 ± 0.58 and 3.66 ± 0.86 m/s in the AH , SAH and FH groups, respectively. The SWV was significantly higher in the FH group than in the other groups ( P < 0.001), and in the SAH group than in the AH group ( P = 0.002). The area under the ROC for predicting FH was 0.924 (sensitivity, 83.3%; specificity, 93.0%). The SWV was significantly increased in non‐survivors, while remaining decreased in survivors ( P = 0.002). Conclusion The SWV measured by ARFI elastography reflects severity of liver damage, and serial changes in SWV predict the prognosis of ALF patients. The SWV is an early and precise biomarker of FH .