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Seroprevalence, genotypic distribution and potential risk factors of hepatitis B and C virus infections among adults in S iem R eap, C ambodia
Author(s) -
Yamada Hiroko,
Fujimoto Mayumi,
Svay Somana,
Lim Olline,
Hok Sirany,
Goto Noboru,
Ohisa Masayuki,
Akita Tomoyuki,
Matsuo Junko,
Do Son Huy,
Katayama Keiko,
Miyakawa Yuzo,
Tanaka Junko
Publication year - 2015
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12367
Subject(s) - hepatitis c virus , hepatitis b virus , seroprevalence , medicine , virology , serology , immunology , genotype , population , hepatitis b , transmission (telecommunications) , virus , antibody , biology , environmental health , biochemistry , electrical engineering , gene , engineering
Aim We investigated hepatitis B virus ( HBV ) and hepatitis C virus ( HCV ) infections among adults in S iem R eap, C ambodia, to consider the prevention strategy in cooperation with the M inistry of H ealth in C ambodia. Methods Serological tests for determining HBV and HCV infections and questionnaires were performed from 2010 to 2012 among the general population in the province of S iem R eap. Multivariate logistic regression analysis was conducted to clarify the factors related to HBV and HCV infections. Results There were 483 participants, comprising 194 men and 289 women (age range, 18–89 years). The prevalence of hepatitis B surface antigen was not very high at 4.6%, while anti‐hepatitis B core (anti‐ HBc ) was high at 38.5%. All HBV DNA samples were classified as genotype C . Anti‐ HBc showed the trend that the older the age, the higher the positive rate ( P = 0.0002). The prevalence of HCV RNA and anti‐ HCV were 2.3% and 5.8%, respectively. HCV RNA was detected in 39.3% of anti‐ HCV positive samples and most of them were classified as genotype 6 (54.5%) and 1 (27.3%). Remarkably, in multivariate logistic regression analysis, history of operation and blood transfusion were significantly associated with the positivity for HBV infection and HCV RNA , respectively. Conclusion Our results showed that operation and blood transfusion were potential risk factors for HBV and HCV infection, respectively, and supposed that horizontal HBV transmission may be frequent in adults in C ambodia. Hence, for reducing HBV and HCV infections, it is necessary to improve the safety of blood and medical treatment.