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Clinical significance of pretreatment serum interferon‐gamma‐inducible protein 10 concentrations in chronic hepatitis C patients treated with telaprevir‐based triple therapy
Author(s) -
Nishikawa Hiroki,
Enomoto Hirayuki,
Nasu Akihiro,
Aizawa Nobuhiro,
Saito Masaki,
Tamori Akihiro,
Kawada Norifumi,
Kimura Toru,
Osaki Yukio,
Nishiguchi Shuhei
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12326
Subject(s) - telaprevir , gastroenterology , medicine , genotype , ribavirin , fibrosis , hepatitis c , immunology , hepatitis c virus , biology , virus , gene , biochemistry
Aim We aimed to determine whether pretreatment serum interferon‐γ‐inducible protein ( IP )‐10 concentration can predict response to telaprevir ( TVR )‐based triple therapy in patients with genotype 1 chronic hepatitis C ( CHC ), and to examine the effects of IP ‐10 concentration on liver histology. Methods Baseline IP ‐10 concentrations were measured in 97 patients with genotype 1 CHC treated with TVR ‐based triple therapy, and the associations between baseline IP ‐10 and treatment outcome were assessed by univariate and multivariate analyses. Associations between baseline serum IP ‐10 concentration and laboratory data and liver histological findings were also investigated. Results Median IP ‐10 concentration in these patients was 461.83 pg/mL (range, 151.35–4297.62). Multivariate analysis showed that IL28B genotype ( P = 0.025) and IP ‐10 level ( P = 0.004) were factors significantly predictive of rapid virological response ( RVR ), whereas in pretreatment factors only, IL28B genotype ( P = 0.001) and liver fibrosis ( P = 0.035) were independent predictors of sustained virological response. Using a cut‐off IP ‐10 concentration of 460 pg/mL, patients with IL28B risk allele and low IP ‐10 had a significantly higher RVR rate than those with high IP ‐10 ( P = 0.005). IP ‐10 concentration was significantly correlated with liver fibrosis ( P = 0.001) and inflammation activity ( P = 0.006) and had the highest areas under the curve for liver histological findings. Conclusion Baseline serum IP ‐10 level is a useful predictor of virological response in patients with genotype 1 CHC treated with TVR ‐based triple therapy, especially in patients with IL28B risk allele. IP ‐10 was well correlated with liver fibrosis and inflammation.