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Significance of mi RNA ‐122 in chronic hepatitis C patients with serotype 1 on interferon therapy
Author(s) -
Kamo Yasuhiro,
Ichikawa Tatsuki,
Miyaaki Hisamitsu,
Uchida Shinjirou,
Yamaguchi Tohei,
Shibata Hidetaka,
Honda Takuya,
Taura Naota,
Isomoto Hajime,
Takeshima Fuminao,
Nakao Kazuhiko
Publication year - 2015
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12317
Subject(s) - ribavirin , medicine , mir 122 , snp , pegylated interferon , interferon , liver biopsy , immunology , hepatitis c virus , hepatitis c , virology , antiviral therapy , clinical significance , single nucleotide polymorphism , microrna , virus , gastroenterology , biopsy , chronic hepatitis , biology , genotype , gene , biochemistry
Aim Peginterferon ( PEG IFN ) and ribavirin combination therapy is a curative treatment for chronic hepatitis C virus ( HCV ) infection, and virological response to IFN therapy has been strongly associated with genetic variation in IL 28 B single nucleotide polymorphisms ( SNP ). Recently, mi RNA 122 (mi R ‐122), which is the most abundant mi RNA in the liver, has been reported to be important for the replication of HCV RNA . Therefore, we investigated the correlation of mi R ‐122 expression with virological response to IFN and other clinical data. Methods A total of 51 patients with HCV infection who were treated with IFN therapy at N agasaki U niversity H ospital from 2006 to 2011 were included in this study. We investigated the correlation of mi R ‐122 expression in liver biopsy specimens with virological response to IFN therapy and other predictors of response, including IL 28 SNP . Results mi R ‐122 expression did not correlate with IL 28 SNP . However, a significant difference was observed in mi R ‐122 expression between patients who showed a sustained virological response ( SVR ) and those who did not ( P < 0.05). Multivariate analysis indicated that mi R ‐122 is an independent predictor of SVR . Conclusion mi R ‐122 expression could be a marker for predicting the outcome of IFN therapy. Therapies targeting miR‐122 may have positive effects not only by directly inhibiting viral propagation but also by ameliorating cholesterol and lipid abnormalities.