Premium
Involvement of platelets in extrahepatic metastasis of hepatocellular carcinoma
Author(s) -
Morimoto Yuki,
Nouso Kazuhiro,
Wada Nozomu,
Takeuchi Yasuto,
Kinugasa Hideaki,
Miyahara Koji,
Yasunaka Tetsuya,
Kuwaki Kenji,
Onishi Hideki,
Ikeda Fusao,
Miyake Yasuhiro,
Nakamura Shinichiro,
Shiraha Hidenori,
Takaki Akinobu,
Yamamoto Kazuhide
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12315
Subject(s) - hepatocellular carcinoma , medicine , platelet , odds ratio , hazard ratio , proportional hazards model , gastroenterology , metastasis , confidence interval , oncology , cohort , multivariate analysis , logistic regression , retrospective cohort study , cancer
Aim Recently, a relationship between platelets and cancer metastasis has been reported. The aim of this study is to elucidate the risk factors for extrahepatic metastasis ( EHM ), with emphasis on association with platelets in patients, with hepatocellular carcinoma ( HCC ). Methods We examined risk factors for EHM in 1613 consecutive, newly diagnosed HCC patients by logistic regression analysis (case–control study). We also examined the factors by C ox proportional hazard model in a retrospective cohort fashion in 803 patients who received non‐curative treatment for HCC . Results In the case–control study, multivariate analysis revealed that high platelet counts (odds ratio [ OR ] = 4.84; 95% confidence interval [ CI ] = 1.29–29.54; P = 0.01), high tumor number and the presence of macroscopic vascular invasion were significantly associated with EHM . In the cohort study, EHM was diagnosed in 71 patients during the study period (mean observation time = 23.3 months). On multivariate analysis, high tumor number, high des‐γ‐carboxyprothrombin ( DCP ) and C hild– P ugh class A were significantly correlated with EHM , and the patients with high platelet counts tended to develop EHM ( OR = 1.73; 95% CI = 0.99–3.14; P = 0.055). Conclusion HCC patients with high platelet counts, as well as large numbers of tumors, high serum DCP and C hild– P ugh class A , are at risk for EHM .