Premium
Pre‐ and postoperative nutritional assessment and health‐related quality of life in recipients of living donor liver transplantation
Author(s) -
Urano Eri,
YamanakaOkumura Hisami,
Teramoto Arisa,
Sugihara Kohei,
Morine Yuji,
Imura Satoru,
Utsunomiya Tohru,
Shimada Mitsuo,
Takeda Eiji
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12263
Subject(s) - medicine , nefa , anthropometry , liver transplantation , quality of life (healthcare) , respiratory quotient , transplantation , liver function , fatty liver , physical therapy , disease , nursing , insulin
Aim The nutritional state of living donor liver transplantation ( LDLT ) recipients is one of the most important factors affecting postoperative outcome. Although the assessment of health‐related quality of life ( HRQOL ) is of increasing importance, few studies have examined this in conjunction with LDLT recipient nutritional state. Methods Ten LDLT recipients with end‐stage liver disease were recruited for this study. Measurements of energy expenditure, anthropometrics and laboratory data were performed before and 1, 6 and 12–24 months after LDLT . HRQOL was measured by using the 36‐item S hort‐ F orm ( SF ‐36) before and 1, 3, 6 and 12–24 months after LDLT . Results The preoperative value of non‐protein respiratory quotient (np RQ ) was 0.796 ± 0.026 and it increased significantly after the operation. Serum non‐esterified fatty acid ( NEFA ) levels were high in the preoperative state, but had significantly decreased 1 month after the operation. A negative correlation between np RQ and NEFA was observed throughout the study period. Cholinesterase and albumin levels improved to normal levels within 6 and 12–24 months, respectively. The recovery of the physical component summary of the SF ‐36 was observed after the improvement of all domains of laboratory data and energy metabolism based on the nutritional state. Conclusion This study demonstrated that the recovery of metabolic function, laboratory data and HRQOL in LDLT recipients are variable, and it took more than 6 months to normalize the liver protein synthetic capacity and physical HRQOL score periods. Therefore, long‐term nutritional support is required in LDLT recipients.