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Elevation of serum cytokines preceding elevation of liver enzymes in a case of drug‐induced liver injury
Author(s) -
Kakisaka Keisuke,
Takikawa Yasuhiro
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12253
Subject(s) - medicine , liver injury , drug , liver enzyme , tumor necrosis factor alpha , pneumonia , diabetes mellitus , gastroenterology , endocrinology , pharmacology
A 50‐year‐old man who was being treated for both pneumonia and type 2 diabetes mellitus complained of abdominal distention on the 16th hospital day. Liver enzyme elevation without symptoms was detected on the 17th hospital day. Based on a R oussel U claf C ausality A ssessment M ethod score of 10 and a J apan D igestive D isease W eek score of 9, we diagnosed the patient as having drug‐induced liver injury ( DILI ). Simultaneous assays of the levels of cytokines revealed that the elevation of the levels of interleukin ( IL )‐1β, IL ‐10, IL ‐12, IL ‐13 and tumor necrosis factor‐α preceded the elevation of the serum liver enzymes. This case suggests that some cytokines or related molecules are potentially useful as early‐phase biomarkers for DILI .