Premium
Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma
Author(s) -
Takahashi Shigeo,
Kimura Tomoki,
Kenjo Masahiro,
Nishibuchi Ikuno,
Takahashi Ippei,
Takeuchi Yuki,
Doi Yoshiko,
Kaneyasu Yuko,
Murakami Yuji,
Honda Yoji,
Aikata Hiroshi,
Chayama Kazuaki,
Nagata Yasushi
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12241
Subject(s) - medicine , portal vein thrombosis , hepatocellular carcinoma , radiology , stenosis , thrombosis , bile duct , portal vein
The aim of this study was to evaluate portal vein and bile duct toxicity after stereotactic body radiation therapy ( SBRT ) for hepatocellular carcinoma ( HCC ). We retrospectively reviewed 63 patients who were administrated SBRT once for HCC . The prescribed doses were from 48 Gy in four fractions to 60 Gy in eight fractions. Portal vein thrombosis and bile duct stenosis were evaluated. The dose received by 2% of the volume ( D 2 ) of the portal vein and bile duct was calculated. Portal vein thrombosis was observed in three patients (4.8%). Common points of these patients were C hild– P ugh class B and D 2 of the portal vein 40 Gy or more ( BED 3 ≥200 Gy). Bile duct stenosis was observed in one patient (1.6%). The patient had a history of cholangiocarcinoma and left hepatic lobectomy. Portal vein thrombosis may be necessary to be considered when SBRT for HCC is administrated to patients in higher C hild– P ugh class with higher D 2 of the portal vein.