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Application of deep sequence technology in hepatology
Author(s) -
Ninomiya Masashi,
Ueno Yoshiyuki,
Shimosegawa Tooru
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12214
Subject(s) - dna sequencing , deep sequencing , sequence (biology) , computer science , dna sequencer , hepatology , computational biology , data science , medicine , biology , genetics , genome , gene , dna
Deep sequencing technologies are currently cutting edge, and are opening fascinating opportunities in biomedicine, producing over 100‐times more data compared to the conventional capillary sequencers based on the S anger method. Next‐generation sequencing ( NGS ) is now generally defined as the sequencing technology that, by employing parallel sequencing processes, producing thousands or millions of sequence reads simultaneously. Since the GS20 was released as the first NGS sequencer on the market by 454 L ife S ciences, the competition in the development of the new sequencers has become intense. In this review, we describe the current deep sequencing systems and discuss the application of advanced technologies in the field of hepatology.