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Living donor liver transplantation for non‐alcoholic steatohepatitis: A single center experience
Author(s) -
Tanaka Tomohiro,
Sugawara Yasuhiko,
Tamura Sumihito,
Kaneko Junichi,
Takazawa Yutaka,
Aoki Taku,
Hasegawa Kiyoshi,
Sakamoto Yoshihiro,
Yamashiki Noriyo,
Kokudo Norihiro
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12200
Subject(s) - medicine , steatohepatitis , liver transplantation , living donor liver transplantation , single center , fatty liver , surgery , alcoholic liver disease , liver disease , retrospective cohort study , gastroenterology , transplantation , disease , cirrhosis
Aim The number of patients referred for liver transplantation ( LT ) with non‐alcoholic steatohepatitis ( NASH ) continues to increase, but information about living donor liver transplantation ( LDLT ) for NASH is scarce. We conducted this study to document the details of LDLT for NASH in a J apanese LT center. Methods Among all LDLT recipients in our institution from M arch 1996 to M arch 2013 ( n = 425), we identified seven patients that underwent LDLT for NASH . Results Of all the seven recipients, most of the patients (86%) were obese. The median follow‐up period post‐ LDLT was 5.3 years. All were alive at the last follow‐up. Recurrent NASH was detected in one patient (14%), and no recurrent hepatic steatosis was detected among the remaining six recipients on prospectively performed ultrasonography. No significant comorbidities were observed following donor surgery among the respective living donors during the follow‐up period. We also retrospectively reviewed 22 patients with NASH ‐related end‐stage liver disease ( ESLD ) who were evaluated but rejected for LDLT during the same period. The reasons for rejection for LDLT were presumably associated with the nature of NAFLD / NASH in either potential recipients or donors. Conclusion The post‐transplant outcome of LDLT for NASH ‐related ESLD in our institution was feasible, although the sample size was small. Further studies in a larger patient cohort are warranted to investigate the long‐term outcome of LDLT for NASH , both for recipients and living donors.