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Prospective comparison of real‐time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients
Author(s) -
Tamaki Nobuharu,
Kurosaki Masayuki,
Matsuda Shuya,
Nakata Toru,
Muraoka Masaru,
Suzuki Yuichiro,
Yasui Yutaka,
Suzuki Shoko,
Hosokawa Takanori,
Nishimura Takashi,
Ueda Ken,
Tsuchiya Kaoru,
Nakanishi Hiroyuki,
Itakura Jun,
Takahashi Yuka,
Matsunaga Kotaro,
Taki Kazuhiro,
Asahina Yasuhiro,
Izumi Namiki
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12179
Subject(s) - medicine , fibrosis , gastroenterology , elastography , liver biopsy , receiver operating characteristic , transient elastography , odds ratio , confidence interval , liver fibrosis , prospective cohort study , pathology , biopsy , radiology , ultrasound
Aim Real‐time tissue elastography ( RTE ) is a non‐invasive method for the measurement of tissue elasticity using ultrasonography. Liver fibrosis ( LF ) index is a quantitative method for evaluation of liver fibrosis calculated by RTE image features. This study aimed to investigate the significance of LF index for predicting liver fibrosis in chronic hepatitis C patients. Methods In this prospective study, 115 patients with chronic hepatitis C who underwent liver biopsy were included, and the diagnostic accuracy of LF index and serum fibrosis markers was evaluated. Results RTE imaging was successfully performed on all patients. Median LF index in patients with F 0–1, F 2, F 3 and F 4 were 2.61, 3.07, 3.54 and 4.25, respectively, demonstrating a stepwise increase with liver fibrosis progression ( P < 0.001). LF index (odds ratio [ OR ] = 5.3, 95% confidence interval [ CI ] = 2.2–13.0) and platelet count ( OR = 0.78, 95% CI = 0.68–0.89) were independently associated with the presence of advanced fibrosis ( F 3–4). Further, LF index was independently associated with the presence of minimal fibrosis ( F 0–1) ( OR = 0.25, 95% CI = 0.11–0.55). The area under the receiver–operator curve ( AUROC ) of LF index for predicting advanced fibrosis (0.84) was superior to platelets (0.82), FIB ‐4 index (0.80) and aspartate aminotransferase/platelet ratio index ( APRI ) (0.76). AUROC of LF index (0.81) was superior to platelets (0.73), FIB ‐4 index (0.79) and APRI (0.78) in predicting minimal fibrosis. Conclusion LF index calculated by RTE is useful for predicting liver fibrosis, and diagnostic accuracy of LF index is superior to serum fibrosis markers.