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Features of hepatitis E virus infection in humans and animals in J apan
Author(s) -
Takahashi Masaharu,
Okamoto Hiroaki
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12175
Subject(s) - hepatitis e virus , subclinical infection , transmission (telecommunications) , hepatitis e , virology , zoonosis , disease , serology , medicine , hepatitis , immunology , environmental health , biology , antibody , genotype , gene , biochemistry , electrical engineering , engineering
In J apan, hepatitis E had long been considered to be a rare liver disease which can be accidentally imported from endemic countries in A sia and A frica, where the sanitation conditions are suboptimal. However, since the identification of the first autochthonous hepatitis E case and hepatitis E viremic domestic pigs in J apan in 2001, our understanding of hepatitis E virus ( HEV ) infection in this country has been changing markedly. This has largely been due to the development of serological and gene‐based diagnostic assays, the accumulation of molecular epidemiological findings on HEV infection in humans and animals (as potential reservoirs for HEV in humans) and the recognition of the importance of zoonotic food‐borne and other routes of transmission of HEV , including blood‐borne transmission. Although it is now evident that autochthonous hepatitis E in J apan is far more common than was previously thought, clinical and subclinical HEV infections indigenous to J apan remain underdiagnosed and their prevalence is still underestimated due to the presence of unknown transmission routes and a low awareness of the infection status by many physicians in J apan. This review focuses on the features of HEV infection in humans and animals, as definitive or potential reservoirs for HEV , in J apan, and updates the current knowledge on the routes of transmission, including zoonotic routes, which are important for the maintenance and spread of HEV in J apan.