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Clinical significance of hepatectomy for primary biliary cirrhosis patients with hepatocellular carcinoma: Report of a single center case series and review of the published work
Author(s) -
Sasaki Kazunari,
Matsuda Masamichi,
Ohkura Yu,
Kawamura Yusuke,
Inoue Masafumi,
Suzuki Yoshiyuki,
Hashimoto Masaji,
Ikeda Kenji,
Kumada Hiromitsu,
Watanabe Goro
Publication year - 2014
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12134
Subject(s) - medicine , hepatocellular carcinoma , hepatectomy , cirrhosis , gastroenterology , liver transplantation , primary biliary cirrhosis , liver function , viral hepatitis , stage (stratigraphy) , surgery , transplantation , resection , paleontology , biology
Aim Hepatectomy for hepatocellular carcinoma ( HCC ) in patients with primary biliary cirrhosis ( PBC ) has seldom been reported, and the clinical significance of this procedure remains unclear, although HCC has often been observed in end‐stage PBC patients. Methods To understand the characteristics of hepatectomy on HCC in PBC patients, we examined seven cases at our institute, as well as 22 reported hepatectomy cases in the E nglish‐language and J apanese published work. Furthermore, to assess the treatment efficacy of hepatectomy for HCC in PBC patients, we compared these patients with viral hepatitis patients who underwent hepatectomies at our institute during the same period. Results In the review of 29 cases, more than 70% of the patients were aged over 65 years, and the mean M ayo risk score was low at 5.17. The resected tumors were mainly solitary (79%), and the median maximum tumor size was 37 mm. Approximately two‐thirds of the patients met the M ilan criteria. In the comparison between the PBC and viral hepatitis cases, there were no differences in the postoperative prognoses, although the tumor size was greater in the PBC cases. Conclusion Hepatectomy for HCC in selected PBC cases is a feasible and potentially curative treatment option, similar to hepatectomy for HCC in viral hepatitis patients. This procedure is particularly useful for patients with preserved liver function who are not ideal candidates for liver transplantation.