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Utility of controlled attenuation parameter measurement for assessing liver steatosis in J apanese patients with chronic liver diseases
Author(s) -
Masaki Keiichi,
Takaki Shintaro,
Hyogo Hideyuki,
Kobayashi Tomoki,
Fukuhara Takayuki,
Naeshiro Noriaki,
Honda Yoji,
Nakahara Takashi,
Ohno Atsushi,
Miyaki Daisuke,
Murakami Eisuke,
Nagaoki Yuko,
Kawaoka Tomokazu,
Tsuge Masataka,
Hiraga Nobuhiko,
Hiramatsu Akira,
Imamura Michio,
Kawakami Yoshiiku,
Aikata Hiroshi,
Ochi Hidenori,
Takahashi Shoichi,
Arihiro Koji,
Chayama Kazuaki
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12094
Subject(s) - steatosis , medicine , fatty liver , gastroenterology , liver steatosis , transient elastography , liver biopsy , confidence interval , chronic liver disease , pathology , cirrhosis , biopsy , disease
Aim Steatosis is a common histological feature of chronic liver disease, especially alcoholic and non‐alcoholic fatty liver disease, as well as chronic hepatitis C . A recent study showed that evaluating the controlled attenuation parameter ( CAP ) with transient elastography was an efficient way of non‐invasively determining the severity of hepatic steatosis. The objective of this study was to prospectively evaluate the utility of CAP for diagnosing steatosis in patients with chronic liver disease. Methods One hundred and fifty‐five consecutive patients with suspected chronic liver disease underwent steatosis diagnosis using CAP , blood sample analyses, computed tomography for assessing the liver/spleen ratio and liver biopsy. Steatosis was graded according to the percentage of fat‐containing hepatocytes: S0 , less than 5%; S1 , 5–33%; S2 , 34–66%; and S3 : more than 66%. Results The CAP was significantly correlated with steatosis grade, and there were significant differences between the CAP value of the S0 patients and those of the patients with other grades of steatosis. S0 and S1 –3 hepatic steatosis were considered to represent mild and significant steatosis, respectively. The CAP values of the patients with mild and significant steatosis were significantly different ( P < 0.0001). The area under the receiver–operator curve ( AUROC ) value of the CAP for diagnosing significant steatosis was 0.878 (95% confidence interval, 0.818–0.939), and the optimal CAP cut‐off value for detecting significant steatosis was 232.5 db/m. In multivariate analysis, the CAP ( P = 0.0002) and the liver to spleen ratio ( P = 0.004) were found to be significantly associated with significant steatosis. Conclusion The CAP is a promising tool for rapidly and non‐invasively diagnosing steatosis.