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Spleen magnetic resonance diffusion‐weighted imaging for quantitative staging hepatic fibrosis in miniature pigs: An initial study
Author(s) -
Chen Xiaoli,
Chen Tianwu,
Zhang Xiaoming,
Li Zhenlin,
Li Hang,
Zeng Nanlin,
Tang Hongjie,
Pu Yu,
Chen Nan,
Yang Qi,
Li Li,
Xie Xianyong,
Hu Jiani
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12076
Subject(s) - spleen , cirrhosis , effective diffusion coefficient , stage (stratigraphy) , medicine , diffusion mri , nuclear medicine , receiver operating characteristic , magnetic resonance imaging , fibrosis , diffusion weighted magnetic resonance imaging , liver fibrosis , pathology , radiology , gastroenterology , paleontology , biology
Aim To determine whether spleen diffusion‐weighted imaging ( DWI ) parameters might classify liver fibrosis stage. Methods Sixteen miniature pigs were prospectively used to model liver fibrosis, and underwent spleen DWI by using b = 300, 500 and 800 s/mm 2 on 0, 5th, 9th, 16th and 21st weekend after the beginning of modeling. Signal intensity ratio of spleen to paraspinous muscles ( S / M ), spleen exponential apparent diffusion coefficient (e ADC ) and apparent diffusion coefficient ( ADC ) for each b‐value were statistically analyzed. Results With increasing stages of fibrosis, S / M for all b‐values showed a downward trend; and spleen e ADC and ADC for b = 300 s/mm 2 showed downward and upward trends, respectively (all P < 0.05). The area under the receiver–operator curve ( AUC ) of spleen DWI parameters was 0.777 or more by S / M for classifying each fibrosis stage, and 0.65 or more by e ADC and 0.648 or more by ADC for classifying stage ≥3 or cirrhosis. Among the spleen DWI parameters, S / M for b = 300 s/mm 2 was the best parameter in classifying stage 1 or more, 2 or more and 3 or more with AUC of 0.875, 0.851 and 0.843, respectively; and spleen eADC for b = 300 s/mm 2 was best in classifying stage 4 with an AUC of 0.988. Conclusion Spleen DWI may be used to stage liver fibrosis.